Ewing sarcoma/primitive neuroectodermal tumor arising in the adrenal gland.
نویسندگان
چکیده
Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) is a malignant small round blue cell neoplasm of presumed neuroectodermal origin that affects bones and soft tissue in children and young adults. Nearly 80% of the patients are younger than 20 years. The tumor cells characteristically express CD99 (MIC2 antigen), a glycoprotein localized on cell membrane. The defining feature of ES/PNET is a characteristic translocation t(11;22)(q24;q12) involving the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11.
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ورودعنوان ژورنال:
- Pathology international
دوره 63 5 شماره
صفحات -
تاریخ انتشار 2013